Zifam CS1/CS2 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Per Zifam CS1 vial Sulbactam Na 500 mg, cefoperazone Na 500 mg. Per Zifam CS2 vial Sulbactam Na 1,000 mg, cefoperazone Na 1,000 mg

Indications/Uses

Treatment of infections eg resp tract infections (upper & lower); UTI (upper & lower); peritonitis, cholecystitis, cholangitis & other intra-abdominal infections; septicemia; meningitis; skin & soft tissue infections; bone & joint infections; pelvic inflammatory disease, endometriosis, gonorrhea & other genital tract infections. Alone or in in combination w/ other antibiotics.

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Dosage/Direction for Use

Adult 2-4 g/day IV or IM 12 hrly. Severe or refractory infections Max: 8 g/day. Patients w/ CrCl 15-30 mL/min Max daily dose: 2 g sulbactam, CrCl <15 mL/min Max daily dose: 1 g sulbactam. Childn 40-80 mg/kg/day (ie 20-40 mg/kg/day cefoperazone activity) in 2-4 equally divided doses. Serious or refractory infections Max: 160 mg/kg/day (ie 80 mg/kg/day cefoperazone activity) in 2-4 equally divided doses. Neonates (1st wk of life) 12 hrly.

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Contraindications

Hypersensitivity to penicillins or cephalosporins.

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Zifam CS1/CS2 detailed prescribing information

Special Precautions

Hepatic disease, biliary obstruction, renal dysfunction. Risk of vit K deficiency. Prolonged use may cause an overgrowth of nonsusceptible organisms. Check periodically the renal, hepatic & hematopoietic systems particularly in neonates. Alcohol consumption. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Diarrhea, nausea, vomiting, maculopapular rash, urticaria, decreased Hb & hematocrit, transient eosinophilia, thrombocytopenia, hypoprothrombinemia, transient elevations of liver function tests.

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Storage

View Zifam CS1/CS2 storage conditions for details to ensure optimal shelf-life.

Description

View Zifam CS1/CS2 description for details of the chemical structure and excipients (inactive components).

Action

View Zifam CS1/CS2 mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Cephalosporins

ATC Classification

J01DD62 - cefoperazone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.

Regulatory Classification

POM

Presentation/Packing

Form

Zifam CS1 injectable powd

Packing/Price

1 g x 1's

Form

Zifam CS2 injectable powd

Packing/Price

2 g x 1's

Zifam CS1/CS2

cefoperazone + sulbactam

Manufacturer:

Zifam Pinnacle

Distributor:

Pyrex